Interleukin-6 (IL-6) Human ELISA Testing
Products are for professional/laboratory use only. Abacus dx is pleased to offer Interleukin-6 (IL-6) human Elisa kits for both IVD & RUO testing.
Demeditec Interleukin-6 human ELISA catalogue no: DMDE4640
– IVD kit for use on serum samples
IBL International Interleukin-6 human ELISA catalogue no. IB30147231
– RUO kit for use on a broad range of samples
The scientific community is currently working hard to fully understand the process of COVID-19 infection and its related immune response. Some recent articles highlight the importance of IL-6 measurement in this context.
Interleukin-6 (IL-6) is a multi-functional cytokine that regulates immune responses, acute phase reactions, haematopoiesis and may play a central role in host defence mechanisms. IL-6 is usually not produced constitutively by normal cells, but its expression is readily induced by a variety of cytokines, lipopolysaccharide or viral infections.
When COVID-19 infects the upper and lower respiratory tract it can cause mild or highly acute respiratory syndrome with consequent release of pro-inflammatory cytokines like IL-61. The increased expression of IL-6 in serum is expected to predict the severity of the 2019-nCoV pneumonia and the prognosis of patients2. The dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-193.
Literature:
1 Conti P, Ronconi G, Caraffa A, Gallenga CE, Ross R, Frydas I, Kritas SK. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020 Mar 14;34(2)
2 Chen L, Liu HG, Liu W, Liu J, Liu K, Shang J, Deng Y, Wei S. Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia. Zhonghua Jie He He Hu Xi Za Zhi. 2020 Feb 6;43(0):E005
3 Tao Liu, Jieying Zhang, Yuhui Yang, Hong Ma, Zhengyu Li, Jiaoyue Zhang, Ji Cheng, Xiaoyun Zhang, Yanxia Zhao, Zihan Xia, Liling Zhang, Gang Wu, Jianhua Yi. The potential role of IL-6 in monitoring severe case of coronavirus disease 2019. medRxiv preprint doi: https://doi.org/10.1101/2020.03.01.20029769
Ordering Information:
|
|
Demeditec |
IBL International |
|
Catalogue No. |
DMDE4640 |
IB30147231 |
|
Kit size |
96 well ELISA |
96 welll ELISA |
|
Regulatory |
IVD |
Research use only |
|
Standard Range |
1.65 – 2058 pg/ml |
1.56 – 100 pg/ml |
|
Sensitivity Analytical |
2 pg/ml |
0.92 pg/ml |
|
Sample Type |
Serum |
Serum, Plasma, Cell culture, supernatant |
|
Volume |
100ul |
50ul |
|
Substrate/Isotype |
TMB 450nm |
TMB 450nm |
