IDS Calcium Metabolism Immunoassays

Products are for professional/laboratory use only.

A Pioneer in Calcium Metabolism Measurement
Immunodiagnostic Systems Limited offer a fully automated portfolio on the IDS-iSYS Multi-Discipline Automated System, for accurate calcium metabolism testing.

This complete panel supports laboratories of all types and sizes in their calcium metabolism testing requirements. These markers of vitamin D deficiency can be measured from a single serum sample tube, to facilitate laboratory workflow efficiency. The IDS-iSYS 25-Hydroxy Vitamin D and IDS-iSYS 1,25-Dihydroxy Vitamin D are also available as traditional Enzyme Immunoassay (EIA) or Radioimmunoassay (RIA) formats. From their beginnings as a pioneer in calcium metabolism, IDS continue to demonstrate their leadership and commitment to the market with over 40 years of innovation.

Vitamin D deficiency results in abnormalities in calcium, phosphorus, and bone metabolism and affects 1 billion people worldwide across all ethnicities and age groups. There are several general population groups at higher risk of vitamin D deficiency including: breast-fed infants, older adults, dark skinned people, limited sun exposure and obesity². Vitamin D is vital for the growth and health of bone, without it, bones will be soft, malformed, and unable to repair themselves normally, resulting in the disease called rickets in children and osteomalacia in adults.

Vitamin D deficiency also causes muscle weakness; affected children have difficulties standing and walking, and the elderly have more frequent falls, increasing risk of fracture². Newer studies show low vitamin D status has been linked to an increased risk of type 1 diabetes mellitus, cardiovascular disease, certain cancers, cognitive decline, depression, pregnancy complications, autoimmunity, allergy, and even frailty³. Low prenatal and neonatal vitamin D status may also increase susceptibility to schizophrenia, type 1 diabetes, and multiple sclerosis (MS) in later life³.

IDS’s comprehensive calcium metabolism panel enables laboratories to measure vitamin D deficiencies in line with the Clinical Practice Guidelines set by the Endocrine Society².

Measuring the level of 25(OH)D is the initial diagnostic test for patients at risk of deficiency. 1,25(OH)₂D is used to investigate disorders acquired and inherited in the metabolism of 25(OH)D and phosphate. This includes chronic kidney disease, hereditary phosphate-losing disorders, oncogenic osteomalacia, pseudovitamin D-deficiency rickets, vitamin D-resistant rickets, as well as chronic granulomaforming disorders such as sarcoidosis and some lymphomas.

For patients with chronic kidney disease and vitamin D deficiency, PTH and serum calcium levels should be monitored in addition to 25(OH)D.

References:

1. Holick, MF., “Vitamin D deficiency”. N. Engl. J. Med. (2007) 357 (3): 266–81. 
2. Holick, MF., et al. “Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline.” The Journal of Clinical Endocrinology & Metabolism 96.7 (2011): 1911-1930.
3. Holick, MF., et al. “Vitamin D for health: a global perspective.” Mayo Clinic Proceedings. Vol. 88. No. 7. Elsevier, 2013.

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