ZytoVision FISH probe for ROS1 translocations

Products are for professional/laboratory use only. 

For patients with advanced lung cancer, the expected median survival is approximately one year however treatment with targeted tyrosine kinase inhibitor (TKI) therapy can improve outcomes for patients who have certain molecular alterations that can be identified by molecular testing¹. The recent update to the CAP/IASLC/AMP guidelines now recommends ROS1 testing should be performed on all patients with advanced lung adenocarcinoma, irrespective of clinical characteristics. It is also recommended that all positive ROS1 IHC results should be confirmed by a molecular or cytogenetic method.

The ZytoLight® SPEC ROS1 Dual Color Break Apart Probe is designed to detect translocations involving the chromosomal region 6q22.1 harboring the ROS proto-oncogene 1, receptor tyrosine kinase (ROS1, a.k.a. MCF3) gene. The ROS1 gene is located on 6q22.1 and encodes a receptor tyrosine kinase. Translocations affecting ROS1 have been detected in glioblastoma, cholangiocarcinoma, and non-small cell lung cancer (NSCLC).

ROS1 rearrangements are thought to define a molecular subset of NSCLC with distinct clinical characteristics that are similar to those observed in patients with ALK rearranged NSCLC.

First evidence suggests that administration of ROS1 kinase inhibitors may represent a very effective therapeutic strategy in NSCLC patients harboring activating ROS1 rearrangements. Accordingly, detection of ROS1 rearrangements using Fluorescence in situ Hybridization might be a helpful tool for the identification of patients likely to respond to ROS1 kinase targeting therapies.

The SPEC ROS1 Dual Color Break Apart Probe is a mixture of two direct labelled probes hybridising to the 6q22.1 band. The orange fluorochrome direct labelled probe hybridises distal, the green fluorochrome direct labeled probe hybridises proximal to the ROS1 breakpoint region at 6q22.1.

Ordering Information:

Reference:

1.  Kalemkerian GP,  et al.  (2018)

Go Back