IDS unique products in cartilage health research and diagnostics

Products are for professional/laboratory use only.

IDS cartilage markers, supporting early identification of cartilage damage by providing dynamic assessment of cartilage destruction.

Features and benefits

• Unique assays for detection of CTX-II and COMP.

• Utilises monoclonal antibodies allowing increased confidence in consistency of product over time without changes in specificity etc. due to different bleeds.

• Ready to use reagents reduces hands-on time for assay preparation and streamlines testing.

• Long shelf life provides a cost-effective solution by reducing wastage due to expired kits.

• Suitable for inclusion on automated plate systems to simplify scale-up of testing volume.

• Supported by comprehensive panel of pre-clinical and clinical markers for assessment of cartilage metabolism.

The role of COMP^1-5 and CTX-II^6-10 in cartilage health has been addressed in several scientific publications.

Publications:

1 Serum levels of cartilage oligomeric matrix protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis – PubMed (nih.gov)

2 Serum levels of cartilage oligomeric matrix protein (COMP): a rapid decrease in patients with active rheumatoid arthritis undergoing intravenous steroid treatment – PubMed (nih.gov)

3 Changes in synovial fluid and serum concentrations of cartilage oligomeric matrix protein over 5 years after anterior cruciate ligament rupture: an exploratory analysis in the KANON trial – PubMed (nih.gov)

4 Serum levels of cartilage oligomeric matrix protein. A predicting factor and a valuable parameter for disease management in rheumatoid arthritis – PubMed (nih.gov)

5 Association between changes in molecular biomarkers of cartilage matrix turnover and changes in knee articular cartilage: a longitudinal pilot study – PubMed (nih.gov)

6 Increased urinary type II collagen helical and C telopeptide levels are independently associated with a rapidly destructive hip osteoarthritis – PMC (nih.gov)

7 Cartilage oligomeric matrix protein, C-terminal cross-linking telopeptide of type II collagen, and matrix metalloproteinase-3 as biomarkers for knee and hip osteoarthritis (OA) diagnosis: a systematic review and meta-analysis (oarsijournal.com)

8 Urinary CTX‐II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study – PMC (nih.gov)

9 Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis – PMC (nih.gov)

10 Clinical and biochemical factors associated with risk of total joint replacement and radiographic progression in osteoarthritis: Data from two phase III clinical trials – PubMed (nih.gov)

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