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There are few resources as valuable to cancer researchers as tissue samples – the biospecimens that patients donate to aid in the search for cancer-related biomarkers.
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An optimal frozen section begins with an evenly and completely frozen tissue block in which the block face to be sectioned is flat and includes a complete, full faced section of the tissue submitted. This section should be free of ice crystal artefacts, knife lines, or tears.
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Abacus dx is a supporter of Know Pathology Know Healthcare, a campaign that strives to help Australians better understand what pathology is and the incredible value that pathology tests provide to healthcare. The initiative is run on behalf of Pathology Awareness Australia (PAA), a group that represents interests across the entire field of pathology in Australia.
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Abacus dx is pleased to share Cell Marque’s Words from our Pathologists article that discusses SATB2 (EP281).
Special AT-rich sequence-binding protein 2 (SATB2) is a recently described marker that functions as a nuclear matrix-associated transcription factor. SATB2 is a nuclear marker suitable for use in panels classifying carcinomas of unknown primary (CUP) origin.
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Thythroblast transformation specific related gene, also known as ERG, is a transcription factor associated with endothelial differentiation as well as prostate malignancy. Studies have shown that anti-ERG compares favorably to CD31 and CD34 antibodies in terms of sensitivity and specificity in the identification of angiosarcoma and hepatic angiosarcoma1-2, and hemangioendotheliomas2. In epithelial tumors, ERG immunostaining shows very high specificity (99%) for prostate carcinoma3.