Devyser FH NGS
THESE PRODUCTS ARE NOT AVAILABLE FOR PURCHASE BY THE GENERAL PUBLIC.
Reduce hands-on time from days to minutes with Devyser’s easy-to-use NGS library prep kit for complete characterization of genes involved in familial hypercholesterolemia.
The Devyser FH NGS* kit is an easy to implement solution for NGS library preparation. With ready-to-use reagents and a user-friendly workflow, it suits both manual and automated processes.
Familial Hypercholesterolemia, also known as Autosomal Dominant Hypercholesterolemia (ADH), can be caused by mutations in the LDLR, APOB, PCSK9, APOE, STAP1 and LDLRAP1 genes, all of which can be detected with Devyser’s FH kit. Raised LDL-cholesterol concentrations can also have a polygenic cause that might explain the variable penetrance of the disease. Devyser’s FH kit enables the analysis of 12 polygenic SNPs influencing the LDL-cholesterol level, and 6 SNPs to predict statin response.
Statin drugs are highly effective in lowering blood concentrations of LDL-cholesterol, with concomitant reduction in risk of major cardiovascular events. Although statins are generally regarded as safe and well-tolerated, there is an interindividual difference in the response to statin treatment and some users may develop muscle symptoms, myopathy. Devyser FH enables the detection of several SNPs associated with treatment effect and adverse reactions to statin therapy.
*Research Use Only.
