ZytoVision’s ZytoLight products allow for reliable, highly sensitive and specific detection of genetic aberrations (e.g. translocations, deletions, amplifications and chromosomal aneuploidies) by using fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue sections, cell samples, blood or bone marrow smears, and metaphase chromosome spreads.

The unique ZytoLight Repeat Subtraction Technique leads to advanced specificity and less background of all our SPEC probes. The CEN probes hybridize to highly repetitive satellite DNA sequences, producing sharp, bright signals specific to each individual chromosome.

ZytoVision has a very wide range of FISH probes. Search by the Chromosome Index, the Gene Index, or by the Indication Index.

 

Product Focus

A uniquely designed ALK/EML4 TriCheck FISH probe for lung cancer diagnosis.

ZytoLight SPEC ALK/EML4 TriCheck Probe

The ZytoLight SPEC ALK/EML4 TriCheck Probe is designed to detect inversions involving the chromosonal region 2p23.1-p23.2 harboring the ALK gene and the chromosonal region 2p21 harboring the EML4 gene. Moreover, using this probe it is possible to discriminate between EML4-ALK inversions and translocations affecting ALK, but not EML4.